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Cancer > P53
The following information is about p53.
p53 Defined
A gene found in every cell in your body. It tells the cell's machinery how to make a protein, also called p53. This protein has several roles in a normal cell, the most important of which is to stop cells dividing if they become damaged - it is a tumour suppressor gene. If the p53 gene in one of your cells becomes damaged and starts to make a protein that does not function properly, that cell can become cancerous. Damaged (mutated) p53 genes are found in nine out of ten cancers.
This definition is in context to Cancer. See more contextual defintions for p53.
Researchers identify protein destructing tumour suppressor p53
Published July 3, 2009, 4:48 am, PharmaBiz
Researchers at The University of Texas, Maryland Anderson Cancer Center have identified a protein that marks the tumour suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.
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Off-site p53 Links, User Submitted
The following links have been collected through user bookmark submission in the p53 category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.
Tue Jun 23
- Cell Death and Differentiatio n - The complexity of p53 stabilization and activation
- http://www.nat ure.com/onc/jo urnal/v17/n8/p df/1202014a.pd f: CK2 phosphorylates p53 at S392
- Casein kinase 2 inhibition decreases hypoxia-induci ble factor-1 activity under hypoxia through elevated p53 protein level -- Hubert et al. 119 (16): 3351 -- Journal of Cell Science
- COP9 signalosome-sp ecific phosphorylatio n targets p53 to degradation by the ubiquitin system
- Mutant p53 forms a complex with Sp1 on HIV-LTR DNA. [Biochem Biophys Res Commun. 2000] - PubMed Result
- Inhibition of HIV-1 replication by RNA interference of p53 expression -- Pauls et al. 80 (3): 659 -- Journal of Leukocyte Biology
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Off-site P53 Research Links
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