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The following information is about Ghrelin.

Ghrelin Defined

A peptide hormone produced predominantly by the stomach.Ghrelin appears to be another hormone produced in almost all gastroenteropancreatic neuroendocrine tumors, has little if any biological activity, and may be useful as a marker for response to therapy.

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Off-site Ghrelin Links, User Submitted

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Tue Jun 9

Sat Jun 6

  • Fatty foods -- not empty stomach -- fire up hunger hormone | Science Blog: "Ghrelin is a hormone that was believed to accumulate during periods of fasting and is found in the body in high concentrations just before meals. It is dubbed the "hunger hormone" because it has been shown that administration of pharmacologica l doses acts in the brain to stimulate hunger and increase food intake in animal models and humans. The ghrelin hormone is unique in that it requires acylation (the addition of a fatty acid) by a specific enzyme (ghrelin O-acyl transferase, or GOAT) for activation. Originally it was assumed that the fatty acids attached to ghrelin by GOAT were produced by the body during fasting. The new data by Tschöp and his team suggests that the fatty acids needed for ghrelin activation actually come directly from ingested dietary fats. Tschöp says, it appears that the ghrelin system is a lipid sensor in the stomach that informs the brain when calories are available, giving the green light to other calorie-consum ing processes such as growing."

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Sat Feb 28

  • Science and Reason: Adiponectin: As we noted in this article back in July, there are several hormones and neurotransmitt ers that have noteworthy effects on appetite and eating behavior, and as a result are of much interest with respect to weight gain (or loss) and obesity. The two mentioned in that article were NPY and PYY. The protein leptin is another hormone of this sort. It is often discussed in connection with obesity, because it is believed to increase metabolism and decrease appetite (as a signal of satiety). Another hormone, ghrelin, is produced in the stomach as a signal of hunger, and so it increases appetite.

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