The following information is about Dacarbazine.

Dacarbazine Defined

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Sun May 11

• Nexavar® May Have Significant Activity in Advanced Melanoma (5/2008, CancerConsulta nts): Researchers associated with a multicenter U.S. Phase II clinical trial have reported that the addition of Nexavar® (sorafenib) improves progression-fr ee survival (PFS) in patients with advanced melanoma receiving dacarbazine.

Tue Mar 11

• Anavex 7-1037 reduces rate of cancer tumor growth 69% in pre-clinical studies, compared to currently marketed drug Dacarbazine showing no measurable activity (3/2008, CNN): "Anavex Life Sciences Corp. -- announced that ANAVEX 7-1037 has demonstrated its ability to significantly delay the growth of cancerous tumors in patient-derive d xenografts during advanced pre-clinical studies."

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