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Cancer > Cytotoxic
The following information is about Cytotoxic.
Cytotoxic Defined
Chemicals that are directly toxic to cells, preventing their reproduction or growth. Cytotoxic agents can, as a side effect, damage healthy, noncancerous tissues or organs that have a high proportion of actively dividing cells - for example, bone marrow or hair follicles. These side effects limit the amount and frequency of drug administration.
This definition is in context to Cancer. See more contextual defintions for Cytotoxic.
PharmaMar Submits Registration Dossier To The EMEA For Yondelis(R) For Treatment Of Relapsed Ovarian Cancer
Published December 4, 2008, 11:14 am, Medical News Today
PharmaMar announced today the submission of a registration dossier to the European Medicines Agency (EMEA) for Yondelis® (trabectedin) when administered in combination with DOXIL®/Caelyx™ (pegylated liposomal doxorubicin) for the treatment of women with relapsed ovarian cancer (ROC).
NCKU Faculty Develop Potent Anticancer Prodrug
Published December 2, 2008, 11:45 pm, Centre Daily Times
Under the rising threat from deadly disease, cancer, Taiwan is faced with the rigorous challenges to develop new drugs or treatment strategy for curing cancers. Professor Tian-Shung Wu of the Department of Chemistry of National Cheng Kung University (NCKU) has successfully isolated and synthesized a potent antineoplastic prodrug, antofine, by making use of organic chemistry to synthesize various ...
NCKU Faculty Develop Potent Anticancer Prodrug
Published December 2, 2008, 11:31 pm, Business Wire via Yahoo! Finance
TAINAN, Taiwan----Under the rising threat from deadly disease, cancer, Taiwan is faced with the rigorous challenges to develop new drugs or treatment strategy for curing cancers. Professor Tian-Shung Wu of the Department of Chemistry of National Cheng Kung University has successfully isolated and synthesized a potent antineoplastic prodrug, antofine, by making use of organic chemistry to ...
Cytotoxic therapies to feel sting of generics
Published December 2, 2008, 3:24 am, Pharmaceutical Business Review
Cytotoxic therapy has been the cornerstone of cancer treatment for many years: indeed, despite a number of unpleasant side effects, the therapy is relatively effective. However, because of this maturity in the market, generics companies remain keen to emulate the success of several cytotoxic brands that have attained blockbuster sales over the years.
Marshall Edwards, Inc. Files IND Application For Triphendiol - Locally Advanced Or Metastatic Pancreatic And Bile Duct ...
Published December 1, 2008, 12:11 pm, Medical News Today
Marshall Edwards, Inc. (NASDAQ: MSHL) today announced that it has filed an application with the United States Food and Drug Administration for an Investigative New Drug (IND) approval to undertake clinical studies with triphendiol as a chemosensitizing agent in combination with gemcitabine.
Marshall Edwards, Inc. Files IND Application for Triphendiol
Published December 1, 2008, 5:10 am, Marketwire via Yahoo! Finance
Marshall Edwards, Inc. today announced that it has filed an application with the United States Food and Drug Administration for an Investigative New Drug approval to undertake clinical studies with triphendiol as a chemosensitizing agent in combination with gemcitabine. The IND application is to enable a Phase Ib study of triphendiol in combination with gemcitabine in patients with ...
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Off-site Cytotoxic Links, User Submitted
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Fri Nov 14
- Cytotoxic substances from plants: Cytotoxic substances are toxic to cells and cause their death. Such compounds are widespread among plants. More importantly, these effects can be used for medical purposes such as suppressing growth of various tumor cells. This chapter provides an overview of the many cytotoxins and the many fungi and plants in which they naturally occur.
Fri Nov 7
- In Vivo - Antimalaria and Cytotoxic Properties of Annona Senegalensis Extract, Annonaceae - University of Ibadan, Nigeria - 2006: The in vivo animal antimalarial and in vitro cytotoxic activities of the methanol extract of Annona senegalensis Pers. (Annonaceae) was investigated in this study. The in vivo antimalarial activity of the methanol extract against Plasmodium berghei was assessed using the 4-day suppressive test procedure. The extract of A. senegalensis had intrinsic antimalarial property that were dose ? dependent. At doses of 100mg/kg weight of mice, it produced significant chemosuppressi on of parasitemia (> 57%) when administered orally. It had the highest activity at 800mg/kg weight of mice (91.1%) compared to Chloroquine disphosphate, the standard reference drug which had a chemosuppressi on of 96.2%.
- In Vitro - Actogenins, anthelmintic, antimalarial, antimicrobial, antiprotozoal, and cytotoxic antitumor - University of Tartu, Estonia: The tropical plant family Annonaceae consists of 130 genera and 2300 different species.[1] However, despite of its relatively large size, the plant family is chemically one of the least explored. The discovery of uvaricin (Fig. 1) in 1982, the first of the acetogenins, as an in vivo active antileukemic (P-388) agent, invigorated wide interest in this family.[2]
Mon Oct 6
- Most Beta-Cells Die via Inflammatory Cytokines, Not Cytotoxic T-lymphocytes | Full Text (PDF)
- Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes -- Seewaldt et al. 49 (11): 1801 -- Diabetes: Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes
Sun Apr 6
- The Australasian Society of Clinical Immunology and Allergy - Unorthodox Techniques for the Diagnosis and Treatment of Allergy, Asthma and Immune Disorders: Allergy is a science-based specialty Modern allergy practice relies on understanding the biological mechanisms underlying allergic disorders (such as asthma, hay fever or food and insect sting allergy). Accurate diagnosis is underpinned by standardized a
Thu Jan 17
Tue Jan 15
- Graviola tree - Gravizon Amazon Herb Company: Graviola - A medium size shrub growing in the Amazon. Has delicious fruit called pawpaw, which is widely consumed by indigenous people. The leaf of the graviola tree contains compounds with cytotoxic activity and prevents abnormal cellular division.
Tue Jun 5
- Hyperthermia Plus Chemotherapy Nearly Doubles Disease-Free Survival Compared to Chemotherapy Alone for Sarcoma Cancer Patients: BSD Medical Corp. (Amex: BSM ) announced today that the results of a 340 patient randomized Phase III clinical trial testing the benefit of adding hyperthermia therapy to chemotherapy were presented at the annual American Society of Clinical Oncology (ASC
Tue Apr 10
- Chemotherapy - Wikipedia, the free encyclopedia: Chemotherapy is the use of chemical substances to treat disease. In its modern-day use, it refers primarily to cytotoxic drugs used to treat cancer. In its non-oncologica l use, the term may also refer to antibiotics (antibacterial chemotherapy). In tha
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