The following information is about Brain Metastasis.

Brain Metastasis Defined

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Off-site Brain Metastasis Links, User Submitted

The following links have been collected through user bookmark submission in the Brain Metastasis category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.

Sun Jun 14

• How Cancers Spread To The Brain

Thu May 7

• BBC News Online: Gene allows cancer to enter brain: Professor Sir David Lane, Cancer Research UK's chief scientist, described the study as "very exciting" . He said: the genes they've identified could become good targets for new drugs as well as some existing medicines, so they offer hope of being able to block this particular form of metastasis.

Fri Jan 30

• NeurosurgeryTo day.org | What is Neurosurgery | Patient Education Materials | brain metastasis

Thu Sep 11

• Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain -- Gril et al. 100 (15): 1092 -- JNCI Journal of the National Cancer Institute: put HER2 into 231 cells. See that lapatinib blocks signaling at 0.5 - 1 uM (Akt and PLCg phosphorylatio n alot, MAPk not so much, they suggest due to mutated ras, also look at EGFR residues and see all but 992 reduced in phosphorylatio n), but then IC50 for growth is 8 uM! also show significant (but not complete) reduction in number of metastases showing pErbB2 staining in mice - do not directly discuss blood brain barrier

Fri Sep 5

• Metastatic Tumors to the Brain and Spine
• Neurologic Complications of Prostate Cancer - May 1, 2002 - American

Wed Jun 13

• Gefitinib as a First-Line Therapy of Advanced or Metastatic Adenocarcinoma of the Lung in Never-Smokers: another article about Iressa/gefitin ib and advanced adenocarcinoma
• Efficacy of erlotinib in the treatment of patients with brain metastasis from non small cell lung cancer.: another study about Tarceva
• Complete response to erlotinib treatment in brain metastases from recurrent NSCLC: you can't see this whole article but the title suggests that brain metastasis responded well to Tarceva/erloti nib
• Gefitinib/Ires sa and Brain Metastasis: a long list of articles on the topic of Iressa and brain metastasis

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Off-site Brain Metastasis Research Links

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