The following information is about Autoimmunity.

Autoimmunity Defined

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Off-site Autoimmunity Links, User Submitted

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Thu Jul 2

• Access : Common variants on chromosome 6p22.1 are associated with schizophrenia : Nature: from the abstract: "Here we show that schizophrenia is significantly associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibi lity complex region on chromosome 6...These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterizati on of these signals will suggest important directions for research on susceptibility mechanisms.&qu ot;

Sun Jun 14

• Alternate Seat of TYR -- Accidental Guerrilla; Part 2, Strategy: "... the grand strategy of Al-Qa?ida can be thought of as auto-immune warfare... The aim is to provoke and manipulate the enemy until their reactions create many more zones of dubious authority where they can move in, and eventually until the West is exhausted economically. ...we are to be destroyed by the over-reaction of our own security system, just as auto-immune diseases turn the immune system on the body. The main-force guerrillas? role is to stage spectaculars, which provide propaganda of the deed, create chaos, and intimidate or chase off the representative s of the state or of traditional authority. The other elements of a classic guerrilla system ? the clandestine administration , and its part-time local guerrilla force ? then step in. Meanwhile, the strike force moves on to other battles or melts back into hiding."
• Boing Boing -- Terrorism is auto-immune war; war-on-terror does the terrorists' job: 'The Yorkshire Ranter recasts terrorism as an "auto-imm une war" -- a war intended to inflict maximum damage by getting the host's defense mechanisms to overfire, damaging the host well beyond than the actual terrorist attacks: "Specific ally, auto-immune war is a strategy, but its tactical implementation is the creation of false positive responses. Security obsession gums up the economy with inefficiencies . Terrorism terrorises the public; security theatre keeps them that way. As Kilcullen points out, every day, millions of travellers are systematically reminded of terrorism by government security precautions. Profiling measures subject entire communities to indignity and waste endless hours of police time. Vast sums of money are spent on counterproduct ive equipment programs and unlikely techno-fixes. National identity cards and monster databases are the specific symptoms of this pathology in the UK, just as idiotic militarism is in the US."' ; -- The cancer that is killing /e

Thu Jun 11

• Interleukins adapt to parasites -- Maxmen 206 (6): 1211 -- The Journal of Experimental Medicine

Sat Jun 6

• Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity -- Guerau-de-Arel lano et al. 0 (2009): jem.20090300v1 -- J. Exp. Med.: There has long been conceptual and experimental support for, but also challenges to, the notion that the initial period of the immune system's development is particularly important for the establishment of tolerance to self. The display of self-antigens by thymic epithelial cells is key to inducing tolerance in the T lymphocyte compartment, a process enhanced by the Aire transcription factor. Using a doxycycline-re gulated transgene to target Aire expression to the thymic epithelium, complementing the Aire knockout in a temporally controlled manner, we find that Aire is essential in the perinatal period to prevent the multiorgan autoimmunity that is typical of Aire deficiency. Surprisingly, Aire could be shut down soon thereafter and remain off for long periods, with few deleterious consequences. The lymphopenic state present in neonates was a factor in this dichotomy because inducing lymphopenia during Aire turnoff in adults recreated the disease, which, ...

Thu Jun 4

• A new lead for autoimmune disease | Science Blog: Halufinogone has been found to reduce autoimmunity in a murine model by activating the amino acid starvation response (AAR) pathway. It does this in all cells, but somehow selectively inhibits the development of Th17 cells, which have been implicated in autoimmune disease. An eventual result of this finding could be a small molecule alternative to general immunosuppress ants.
• Welcome | Immune Disease Institute

Mon Jun 1

• Thymic stromal lymphopoietin: master switch for allergic inflammation -- Liu, 10.1084/jem.20 051745 -- The Journal of Experimental Medicine

Mon May 18

• Narcolepsy Is An Autoimmune Disorder, New Research Shows: HLA and this T cell variant interact in a way that kills hypocretin cells.

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Off-site Autoimmunity Research Links

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