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Cancer > Animal Model
The following information is about Animal Model.
Animal Model Defined
An animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models.
This definition is in context to Cancer. See more contextual defintions for Animal Model.
First Ever In-vivo Efficacy Data For A MicroRNA Therapeutic Disease Model
Published December 1, 2008, 12:10 pm, Medical News Today
Regulus Therapeutics LLC, a joint venture between Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY) and Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) formed to discover, develop, and commercialize microRNA-based therapeutics, announced today the publication of new research in the journal Nature on the role of a microRNA, known as miR-21, in heart failure(1).
Combining Targeted Therapy Drugs May Treat Previously Resistant Tumors
Published December 1, 2008, 6:12 am, Medical News Today
A team of cancer researchers from several Boston academic medical centers has discovered a potential treatment for a group of tumors that have resisted previous targeted therapy approaches.
Drug combo may help treat previously resistant tumours
Published December 1, 2008, 1:25 am, New Kerala
London, Dec 1 : A team of scientists has discovered a potential treatment for a group of tumours that have resisted previous targeted therapy approaches.
Combining Targeted Therapy Drugs May Treat Previously Resistant Tumors
Published November 30, 2008, 2:25 pm, Science Daily
Cancer researchers have discovered a potential treatment for a group of tumors that have resisted previous targeted therapy approaches. They found that blocking 2 cell signaling pathways leads to a dramatic shrinkage of K-Ras-mutated tumors in an animal model.
Combining targeted therapy drugs may treat previously resistant tumors
Published November 30, 2008, 10:27 am, EurekAlert!
( Massachusetts General Hospital ) A team of cancer researchers from several Boston academic medical centers has discovered a potential treatment for a group of tumors that have resisted previous targeted therapy approaches. In their Nature Medicine report, receiving early online release, the investigators report that combining two different kinase inhibitors -- drugs that interfere with ...
Regulus Therapeutics, Alnylam Pharmaceuticals, and Collaborators Publish First Ever In Vivo Efficacy Data for a ...
Published November 30, 2008, 10:21 am, Finanzen.net
Regulus Therapeutics LLC, a joint venture between Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY) and ...
Regulus Therapeutics, Alnylam Pharmaceuticals, and Collaborators Publish First Ever In Vivo Efficacy Data for a ...
Published November 30, 2008, 10:16 am, Centre Daily Times
Regulus Therapeutics LLC, a joint venture between Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY) and Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) formed to discover, develop, and commercialize microRNA-based therapeutics, announced today the publication of new research in the journal Nature on the role of a microRNA, known as miR-21, in heart failure (1) . The new findings demonstrated that miR-21 ...
Cancer linked specific protein's inactivation halts prostate tumour progression in animal model: USC
Published November 29, 2008, 2:50 am, PharmaBiz
University of South California (USC) researchers have found that inactivating a specific biomarker for aggressive prostate cancer blocks the development of prostate cancer in animal models.
Pharmacyclics Announces Completion Of Phase 1 Clinical Trial Of Factor VIIa Inhibitor PCI-27483
Published November 26, 2008, 3:11 am, Medical News Today
Pharmacyclics, Inc. (Nasdaq: PCYC) announced that the company has completed a Phase 1 clinical trial with PCI-27483, the company's novel, first-in-class small-molecule Factor VIIa inhibitor. The trial was conducted in sixteen (16) healthy volunteers to evaluate the safety and pharmacologic effect of PCI-27483.
USC Researchers Identify Novel Approach For Suppressing Prostate Cancer Development
Published November 25, 2008, 5:13 am, Medical News Today
Inactivation of a specific protein associated with cancer development halts prostate tumor progression in animal model Los Angeles, Calif. Nov. 24, 2008 California (USC) have found that inactivating a specific biomarker for aggressive prostate cancer blocks the development of prostate cancer in animal models.
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Off-site Animal Model Links, User Submitted
The following links have been collected through user bookmark submission in the Animal Model category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.
Sat Nov 8
- WARNING - Parkinson's, Epidemiologica l and animal model studies, Mitochondrial dysfunction - Emory University, Atlanta, Georgia, Parkinson's Institute, Sunnyvale, California - 2006: Parkinson' ;s disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration and development of cytoplasmic proteinaceous aggregates known as Lewy bodies. Although the pathogenic mechanisms responsible for PD are not completely understood, many clues have come from biochemical, epidemiologica l, and genetic studies. Mutations in certain genes found in rare, familial cases of PD, such as ?-synuclein and parkin, suggest a role for the ubiquitin-prot eosome system and aberrant protein aggregation. Biochemical analyses have implicated mitochondrial dysfunction in PD. Epidemiologica l and animal model studies point to a role for environmental toxins, some of which are mitochondrial inhibitors. Mitochondrial dysfunction, resulting from either genetic defects, environmental exposures or an interaction between the two, may cause ?-synuclein aggregation or neurodegenerat ion through oxidative stress or excitotoxicity .
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