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Mon Jun 29

• Bevacizumab Not Beneficial in Early Colon Cancer, CO-8 results: Don't use Bev as adjuvant Rx

Tue Jun 23

• CancerMath.net

Sun May 31

• Medical News: ASCO: Targeted Therapy Misses the Mark in Early Colorectal Cancer - in Meeting Coverage, ASCO from MedPage Today: Bevacizumab (Avastin) did not demonstrate significant efficacy in early colorectal cancer - watch an embedded video of the experts discussion. Interesting.

Wed May 27

• Cancer Help And Advice: melanoma chemotherapy. side effects of chemotherapy: Breast chemotherapy refers to the treatment applied to patients who suffer from breast cancer. Its purpose is to kill or to reduce in size the tumor consisting of cells that multiply very quickly compared to the normal rate of multiplication of normal cells.

Thu Apr 23

• Genentech: Newsroom: Press Releases: News Release April 21, 2009: "While we are disappointed the C-08 study did not meet its primary endpoint, our initial review of the data leads us to continue to believe Avastin may be active in patients with early-stage colon cancer and look forward to NSABP's presentation at ASCO," said Hal Barron, M.D., senior vice president, Development and chief medical officer, Genentech. "We remain fully committed to the ongoing Avastin adjuvant programs in early-stage colon, breast and lung cancers."
• Bevacizumab Study in Early-Stage Colon Cancer Misses Primary Endpoint - OncologySTAT: Genentech, Inc., announced today that the National Surgical Adjuvant Breast and Bowel Project (NSABP) C-08 study did not meet its primary endpoint of improved disease-free survival (DFS) with adjuvant use of bevacizumab (Avastin®) plus chemotherapy in patients with early-stage colon cancer. This was based on results from the final analysis of the NSABP C-08 study, a randomized multinational phase III study designed to evaluate the efficacy of adjuvant 5-fluorouracil , leucovorin, and oxaliplatin (FOLFOX), with or without bevacizumab, in patients with resected stage II or III adenocarcinoma of the colon. Bevacizumab is already approved by the US Food and Drug Administration for the treatment of metastatic colorectal cancer. This is the first phase III study of bevacizumab in early-stage disease.

Mon Apr 13

• Acacia Pharma - Acacia Pharma Ltd, Cambridge
• Competitor - Cisplatin - Wikipedia, the free encyclopedia - Paclitaxel adjuvant Taxol: Cisplatin is a platinum-based chemotherapy drug used to treat various types of cancers. It was the first member of its class, which now also includes carboplatin and oxaliplatin. Platinum complexes are formed in cells, which bind and cause crosslinking of DNA; ultimately triggering apoptosis(prog rammed cell death). Cisplatin combination chemotherapy is the cornerstone of treatment of many cancers. Initial platinum responsiveness is high but the majority of cancer patients will eventually relapse with cisplatin-resi stant disease. Many mechanisms of cisplatin resistance have been proposed including changes in cellular uptake and efflux of the drug, increased detoxification of the drug, inhibition of apoptosis and increased DNA repair. Oxaliplatin is active in highly cisplatin-resi stant cancer cells in the laboratory only to date. The drug Paclitaxel may be useful in the treatment of cisplatin-resi stant cancer; the mechanism for this activity is unknown.

Fri Mar 13

• F5506 Freund?s Adjuvant, Incomplete liquid

Mon Mar 2

• Expert Reviews calling for better research on vaccine adjuvants

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